Pseudotyped Lentiviral Vectors: One Vector, Many Guises

Pattern Inference under many Guises

Evaluation Comes in Many Guises

As the information visualisation (infovis) community matures, the evaluation of information visualisation techniques is becoming more of a requirement and less of an optional extra. Unfortunately, the term evaluation means different things to different people. Simply encouraging “evaluation” is too general and imprecise. There is a need for clarification as to what kind of evaluation is expecte...

Beta thalassemia gene therapy using lentiviral vectors

Recent years, allogeneic bone marrow transplantation (BMT) has proved to be the successful cure for patients with thalassemia major, however this is restricted due to limited matched-related donor. Its complications include chronic graft-versus-host disease in 5-8% of patients. So, a molecular approach, such as gene therapy for direct normal beta globin gene transmission, seems quite promising ...

Pseudotyped Lentiviral Vectors for Retrograde Gene Delivery into Target Brain Regions

Gene transfer through retrograde axonal transport of viral vectors offers a substantial advantage for analyzing roles of specific neuronal pathways or cell types forming complex neural networks. This genetic approach may also be useful in gene therapy trials by enabling delivery of transgenes into a target brain region distant from the injection site of the vectors. Pseudotyping of a lentiviral...

Selective transduction of malignant glioma by lentiviral vectors pseudotyped with lymphocytic choriomeningitis virus glycoproteins.

Malignant gliomas are the most frequent primary brain tumors and have a dismal prognosis due to their infiltrative growth. Gene therapy using viral vectors represents an attractive alternative to conventional cancer therapies. In a previous study, we established lentiviral vectors pseudotyped with lymphocytic choriomeningitis virus (LCMV) glycoproteins (GPs) and demonstrated transduction of hum...